Concept information
Preferred term
type II transmembrane serine protease
Definition(s)
- Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene. (Wikipedia)
- Viral entry requires not only binding to the ACE2 receptor but also priming of the virus’s spike (S) protein by the transmembrane protease serine 2 (TMPRSS2) by cleavage of the S proteins at the S1/S2 and S2 sites. Baughn, L. B., et al. (2020). "Targeting TMPRSS2 in SARS-CoV-2 Infection." Mayo Clin Proc 95(9): 1989-1999.
Broader concept(s)
Synonym(s)
- membrane-anchored serine protease, TMpRSS2
- membrane-bound serine protease TMPRSS2
- serine protease
- serine protease TMpRSS2
- TMpRSS2 protease
- transmembrane protease serine 2
- transmembrane serine protease 2
- transmembrane serine protease TMpRSS2
Creator
- Patricia Fener
In other languages
-
French
-
sérine protéase transmembranaire-2
-
TMPRSS2
URI
http://data.loterre.fr/ark:/67375/C0X-NF3PGZJB-5
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