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Concept information

Preferred term

Glucose-6-Phosphate Isomerase  


  • An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.

Broader concept(s)


  • D-Glucose-6-phosphate ketol-isomerase
  • EC
  • Glucose 6 Phosphate Isomerase
  • Glucosephosphate Isomerase
  • Isomerase, Glucose-6-Phosphate
  • Phosphoglucose Isomerase
  • Phosphohexose Isomerase

In other languages

  • French

  • D-glucose 6-phosphate ketol-isomerase
  • D-Glucose-6-phosphate ketol-isomerase
  • EC
  • Hexosephosphate isomérase
  • Oxoisomérase
  • Phosphoglucoisomérase
  • Phosphohexose isomérase
  • Phosphosaccharomutase


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