Concept information
Preferred term
Glucose-6-Phosphate Isomerase
Definition(s)
- An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Broader concept(s)
Synonym(s)
- D-Glucose-6-phosphate ketol-isomerase
- EC 5.3.1.9
- Glucose 6 Phosphate Isomerase
- Glucosephosphate Isomerase
- Isomerase, Glucose-6-Phosphate
- Phosphoglucose Isomerase
- Phosphohexose Isomerase
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
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French
-
D-glucose 6-phosphate ketol-isomerase
-
D-Glucose-6-phosphate ketol-isomerase
-
EC 5.3.1.9
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Hexosephosphate isomérase
-
Oxoisomérase
-
Phosphoglucoisomérase
-
Phosphohexose isomérase
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Phosphosaccharomutase
URI
http://data.loterre.fr/ark:/67375/JVR/M0009354
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